Bench-Top Syringe & Cartridge Closing Machine

Bench-top Syringe & Cartridge Closing System 

AST’s Container Closing System (CCS) is a bench-top, semi-automatic machine that provides complete and accurate control of the syringe and cartridge closing process.  The Container Closing System's flexible design can close syringes or cartridges using both vacuum and vent-tube mechanical methods for placing the piston into the syringe or cartridge.

The syringe and cartridge closing process is electronically controlled to precisely position the piston into the syringe or cartridge under optimized conditions every time.  The vacuum insertion process utilizes AST's patented multi-stage vacuum insertion method with a mechanical assist and is an ideal option for processing West CZ syringes and biologic applications.  The vent-tube or mechanical process can also be used in place of vacuum by simply changing a few format parts. 

The operator interacts with an intuitive, high-resolution touchscreen interface to create unique recipes, monitor the process and control the machine. The advance motion control system can record critical process parameters in the system's database and can be used to create a batch report upon completion of the batch.  This information can also be exported and viewed within Excel for batch analysis and process optimization.

Syringe & Cartridge Closing Capabilities

The system can be quickly and easily changed to close any commercially available glass or plastic prefilled syringe or cartridge.  The container closing flexibility makes the closing machine and ideal tool for any small batch processing application for prefilled syringes or cartridges.

Applications include:

  • R&D, preclinical and process development
  • Clinical trial materials manufacturing
  • Personalized medicine
  • Pilot scale manufacturing
  • Compounding pharmacies
  • Stability studies


  • Automated syringe and cartridge piston placement
  • Performs vacuum and vent-tube piston insertion
  • Simple format change-over
  • Fully controlled and monitored piston insertion
  • Historical process data accessible with Excel
  • Intuitive machine interface
  • Compact system footprint allows for placement with an isolator, biological safety cabinet or LAF

The Container Closing System (CCS) is a semi-automatic bench top machine specifically designed for automated insertion of pistons into pre-filled syringes and cartridges.  The system is ideal for semi-automatic processing of small batch production in the laboratory or cGMP settings.  The system’s flexibility allows processing of glass and plastic syringes ranging from 0.5mL to 20mL with the ability to handle a variety of piston combinations using both the vacuum and vent-tube (mechanical) methodologies. 

The pre-filled syringes or cartridges and the pistons are manually placed on the machine by the operator.  Once the syringes or cartridges are positioned the Container Closing System (CCS) places the piston using vent-tube or vacuum. 

AST’s patented multi-stage vacuum insertion process to evacuate the syringe or cartridge then gently places the piston into its final desired depth using an electronically controlled insertion rod.  This is the ideal closing process for biologic products that might be susceptible to long term oxidation and is the preferred approach for West CZ syringes and cartridges.

The systems advanced motion control system allows operators to conveniently carry out all parameter adjustments directly at the touchscreen interface without manual mechanical adjustments.  The control system has direction position feedback to ensure that the piston is located precisely every time.  In addition to providing intuitive operation and recipe management, the control system can, as an option, create batch reports that monitor and record critical process parameters.  This information can be printed or stored directly to the user’s information system.

The aseptic and compact design of the machine makes it well suited for cGMP environments and can be placed within isolators, biological safety cabinets or laminar air flow (LAF) hoods.  The system is completely compatible isolator bio-decontamination using hydrogen peroxide, and can be manually cleaned using common reagents like isopropyl alcohol and sporicides.

Coming Soon

Technical Information

Dimensions (LxWxH):

725mm x 500mm x 630mm


Syringes & Cartridges

Syringe Sizes:

0.5mL - 20mL

Cartridge Sizes:


Production Rate:

Up to 15 cycles per minute

Placement Accuracy:


Electrical Utilities:

110/220VAC – 60/50Hz.

Materials of Construction:

Pharmaceutical grade stainless steels and plastics

Available Options:

  • Batch reporting
  • GAMP5 & Commissioning documentation
  • Overlay gassing with vent-tube process

*Figures are typical.  Actual performance results vary depending upon application requirements. 



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