Bench-Top Vial Sealing Machine

Semi-Automatic Vial Sealing for Small Batch Processing

AST's Vial Sealing System (VSS) is a bench top, semi-automatic machine used for sealing or capping of pharmaceutical vials and bottles with aluminum caps.  The Vial Sealing System is ideal for development, pre-clinical, clinical, pilot and compounding pharmacy applications.  The VSS provides complete and precise control of the container sealing or capping operations to ensure the highest quality vial seal. The system is specifically designed to meet the unique challenges of small batch lab and cGMP applications.  The system’s versatility allows processing a wide range of vial or bottle sizes and finishes.

Vial Sealing System Process 

The vials or bottles are manually placed on the machine by the operator.  Once placed, the sealing process is initiated, and the sealing head moves down to compress the vial stopper until the closed loop compression force feedback confirms the operator programmed compression setting is achieved.  With the stopper compressed the vial is rotated and the free spinning disk gently forms the aluminum skirt of the cap around the neck of the vial.  This sealing process maintains the compression of the rubber stopper, generates fewer particles and provides a pharmaceutically aesthetic seal without the witness marks common to jaw style crimpers.

The system's compact design and materials of construction make placement within commercially available isolators, bio-safety cabinets or laminar flow hoods (LAFs) simple.  The system's versatility, features, and compact size makes it ideally suited for labs and cGMP environments for small batch pharmaceutical capping applications.

Applications include:

  • R&D, preclinical and process development
  • Clinical trial materials manufacturing
  • Pilot scale cGMP manufacturing
  • Personalized medicine
  • Compounding pharmacies
  • Stability studies

Advanced Vial Sealing Features 

  • High-resolution touchscreen interface to control and monitor the sealing process.
  • Electronic Batch Reporting system for batch documentation, process analysis, and technology transfer and optimization.
  • Compact Design makes it well suited for aseptic environments provides by isolators, biological safety cabinets or laminar air flow (LAF) hoods.


  • Consistent, high quality vial seal
  • Ability to process a wide range of vials and vial finishes
  • Automatic sealing head adjustment
  • Simple format change-over
  • Programmable compression force & crimping speed
  • Closed loop feedback for compression force improves Container Closure Integrity (CCI)
  • Sealing process generates few particles
  • Compact system footprint allows for placement with an 

Versatile & Compact Semi-Automatic filling machine for vials, syringes & Cartridges

Ideal for small batches in laboratory or cGMP settings

Accurate dispensing and filling cycles

Advanced control system with a touchscreen and batch reports

Manual cleaning capabilities with reagents such as isopropyl and sporicides

Coming Soon

Technical Information

Dimensions (LxWxH)

725mm x 500mm x 630mm


Vials & Bottles

Vial Finish:

13mm, 20mm, 32mm

Vials Sizes (Dia./Height):

Ø16mm-47mm / 35mm-100mm

Aluminum Seal / Cap Type:

DIN standard with or without flip-top

Sealing Method:

Spinning roller

Production Rate:

Up to 15 cycles per minute

Electrical Utilities:

110/220VAC – 60/50Hz.

Air Supply:

Clean dry air 7 bar, 0.5L/min free air

Materials of Construction:

Pharmaceutical grade stainless steels and plastics


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